Hydrazine hydrate (1:1) → HCID 178512516, compound

HRID 1758690Notes

Reaction equation

HRID 1758690 reaction equation
Cl.[NH:2]([C:6]1[CH:7]=[C:8]([CH:24]=[CH:25][CH:26]=1)[O:9][CH2:10][CH2:11][CH2:12][N:13]1C(=O)C2=CC=CC=C2C1=O)[C:3]([NH2:5])=[NH:4].O.NN>C(O)C>[NH:2]([C:6]1[CH:7]=[C:8]([CH:24]=[CH:25][CH:26]=1)[O:9][CH2:10][CH2:11][CH2:12][NH2:13])[C:3]([NH2:5])=[NH:4]

Participants

4

Reactant 2

HCID 24654Hydrazine hydrate (1:1)HCID 178479378HCID 178479378, compound

Product 1

HCID 178512516HCID 178512516, compound

Reagents, catalysts & solvents 1

HCID 702EthanolSolvent

Procedure

To a partial suspension of N-[3-(3-guanidinophenoxy)propyl]phthalimide hydrochloride (1.0 g; 2.95 mmoles) in 10 ml of 95% aqueous ethanol was added 0.27 ml of hydrazine hydrate. The mixture was stirred at ambient temperature for 17 hours and evaporated under reduced pressure to give the title compound. The product was used without further purification in Step E.

Workup

  1. customevaporated under reduced pressure

Sources & evidence

ORD record
ord-c6ec05155eba425d9ac1dca9aa7c3c9b
Source dataset
uspto-grants-1983_02
Patent number
US04374248

Reaction notes

Loading…