4-Bromo-4'-hydroxybiphenyl → 4'-Hydroxy-4-biphenylcarbonitrile

HRID 1758699Notes

Reaction equation

HRID 1758699 reaction equation
Br[C:2]1[CH:7]=[CH:6][C:5]([C:8]2[CH:13]=[CH:12][C:11]([OH:14])=[CH:10][CH:9]=2)=[CH:4][CH:3]=1.[Cu][C:16]#[N:17]>>[C:16]([C:2]1[CH:7]=[CH:6][C:5]([C:8]2[CH:13]=[CH:12][C:11]([OH:14])=[CH:10][CH:9]=2)=[CH:4][CH:3]=1)#[N:17]

Participants

3

Reactant 2

HCID 950934-Bromo-4'-hydroxybiphenylHCID 178418546HCID 178418546, compound

Product 1

HCID 1406104'-Hydroxy-4-biphenylcarbonitrile

Procedure

4'-Bromo-4-hydroxybiphenyl is reacted with copper (I) cyanide to obtain 4'-cyano-4-hydroxybiphenyl (this substance is known), which is then reacted with a β-alkyloxyethylbromide in the presence of an alkaline material.

Sources & evidence

ORD record
ord-fb4dc43360df44e59e6a691aef465d5f
Source dataset
uspto-grants-1983_02
Patent number
US04374748

Reaction notes

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