HuagongsheHuagongshe Chemistry Print Report · For research reference only
Sodium Hydroxide → 7-[3-[4-(3-Phenylthio-propyl)-1-piperazinyl]-propyl]-theophylline
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Sodium Hydroxide | HCID 14798 | — |
| Reactant | 7-(3-Chloropropyl)-3,7-dihydro-1,3-dimethyl-1H-purine-2,6-dione | HCID 76011 | — |
| Reactant | 1-(3-(Phenylthio)propyl)piperazine | HCID 2195492 | — |
| Product | 7-[3-[4-(3-Phenylthio-propyl)-1-piperazinyl]-propyl]-theophylline | HCID 3061739 | — |
Reaction Steps
7-(3-Chloropropyl)-theophylline (1 mole) and 1-(3-phenylthiopropyl)-piperazine are refluxed for 24 hours in a 50% aqueous-alcoholic solution. On completion of the reaction, sodium hydroxide (1 mole) is then added. The mixture is extracted with methylene chloride and washed with water, after which the solvent is evaporated off and the residue is recrystallized from ethanol.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US04374835 |
| Source dataset | uspto-grants-1983_02 |
| ORD ID | ord-ff943f179a204bf99252551d0e6d29af |
| Source note | uspto-grants-1983_02 |