HuagongsheHuagongshe Chemistry Print Report · For research reference only
1-(3-(Phenylthio)propyl)piperazine → Tazifylline
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 1-(3-(Phenylthio)propyl)piperazine | HCID 2195492 | — |
| Reactant | 7-(2,3-Epoxypropyl)theophylline | HCID 2775876 | — |
| Solvent | Ethanol | HCID 702 | — |
| Product | Tazifylline | HCID 54424 | — |
Reaction Steps
A solution of ethanol (2 liters) containing 7-(2,3-epoxypropyl)-theophylline (1 mole) and 1-(3-phenylthiopropyl)-piperazine (1 mole) is refluxed for 5 hours. The ethanol is partly removed. The reaction medium crystallizes. The resulting crystals are suction filtered and may be recrystallized from ethanol.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US04374835 |
| Source dataset | uspto-grants-1983_02 |
| ORD ID | ord-9c38a62d0d004b20b48bff9768e2de24 |
| Source note | uspto-grants-1983_02 |