Potassium Carbonate → HCID 13108891, compound

HRID 1758706Notes

Reaction equation

HRID 1758706 reaction equation
Cl.Cl.[N:3]1([CH2:16][CH:17]([OH:35])[CH2:18][N:19]2[CH2:24][CH2:23][N:22]([CH2:25][CH2:26][CH2:27][S:28][C:29]3[CH:34]=[CH:33][CH:32]=[CH:31][CH:30]=3)[CH2:21][CH2:20]2)[C:14](=[O:15])[C:13]2[N:11]([CH3:12])[CH:10]=[N:9][C:8]=2[N:6]([CH3:7])[C:4]1=[O:5].C(=O)([O-])[O-].[K+].[K+]>CCOCC>[N:3]1([CH2:16][CH:17]([OH:35])[CH2:18][N:19]2[CH2:20][CH2:21][N:22]([CH2:25][CH2:26][CH2:27][S:28][C:29]3[CH:30]=[CH:31][CH:32]=[CH:33][CH:34]=3)[CH2:23][CH2:24]2)[C:14](=[O:15])[C:13]2[N:11]([CH3:12])[CH:10]=[N:9][C:8]=2[N:6]([CH3:7])[C:4]1=[O:5]

Participants

4

Reactant 2

HCID 11430Potassium CarbonateHCID 70534380HCID 70534380, compound

Product 1

HCID 13108891HCID 13108891, compound

Reagents, catalysts & solvents 1

HCID 3283Diethyl EtherSolvent

Procedure

1.0 g of 1-(3-theobromin-1-yl-2-hydroxypropyl)-4-(3-phenylthiopropyl)piperazine 2 HCl suspended in 50 ml of ether is stirred with excess dilute aqueous potassium carbonate solution until the salt is completely dissolved. The organic layer is then separated, washed twice with water, dried over magnesium sulfate and evaporated to yield 1-(3-theobromin-1-yl-2-hydroxypropyl)-4-(3-phenylthiopropyl)piperazine as the free base.

Workup

  1. dissolutionis completely dissolved
  2. customThe organic layer is then separated
  3. washwashed twice with water
  4. dry with materialdried over magnesium sulfate
  5. customevaporated

Sources & evidence

ORD record
ord-0a352295890e4bbdb96c08a2dd119929
Source dataset
uspto-grants-1983_02
Patent number
US04374837

Reaction notes

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