反应详情

18.1 g. (64.9 mmole) of 5-(N-acetylamino)-12-methyl-5,6,7,12-tetrahydrodibenzo[a,d]cyclooctene in 200 ml. of dry tetrahydrofuran was treated with 0.3 g. of triphenylmethane and stirred in an ice bath under nitrogen. The amide solution was added dropwise from the addition funnel at a rate sufficiently slow to maintain the reaction temperature below 15° C., until the color of the triphenylmethide anion persisted. The mixture was stirred for 15 minutes in the ice bath, then treated with 20 ml. (45.6 g., 314 mmole) of methyliodide added rapidly (<5 min). The resulting solution was stirred for 2 hours, with the temperature held below 30° C. by ice cooling as necessary, then treated with 30 ml. of water. Nitrogen was bubbled through the mixture overnight, and the remaining liquid evaporated in vacuo. The residue was treated with 300 ml. of water and extracted three times with chloroform. The chloroform extracts were washed once with dilute sodium bisulfite solution and twice with water, dried over potassium carbonate, filtered, and evaporated in vacuo to 33 g. of red oil. The oil was washed four times with petroleum ether and evaporated in vacuo to give 16.0 g. of foam which was dissolved in 10 ml. of warm toluene, diluted with 250 ml. of diethyl ether, and refrigerated overnight to precipitate unreacted starting amide. The solution was filtered and the filtrate was evaporated in vacuo to give 5-(N-acetyl-N-methylamino)-12-methyl-5,6,7,12-tetrahydrodibenzo[a,d]cyclooctene, (10.5 g.) as an orange oil.

1. temperatureto maintain the reaction temperature below 15° C.
2. additiontreated with 20 ml
3. customheld below 30° C. by ice cooling
4. additionthen treated with 30 ml
5. customNitrogen was bubbled through the mixture overnight
6. customthe remaining liquid evaporated in vacuo
7. additionThe residue was treated with 300 ml
8. extractionof water and extracted three times with chloroform
9. washThe chloroform extracts were washed once with dilute sodium bisulfite solution and twice with water
10. dry with materialdried over potassium carbonate
11. filtrationfiltered
12. customevaporated in vacuo to 33 g
13. washThe oil was washed four times with petroleum ether
14. customevaporated in vacuo
15. customto give 16.0 g
16. dissolutionof foam which was dissolved in 10 ml
17. customof diethyl ether, and refrigerated overnight to precipitate unreacted
18. filtrationThe solution was filtered
19. customthe filtrate was evaporated in vacuo