6-(2-Chlorophenyl)-1-methyl-4H-[1,2,4]triazolo[4,3-a][1,4]benzodiazepin-8-amine → HCID 20508562, compound

HRID 1758786Notes

Reaction equation

HRID 1758786 reaction equation
FC1C=CC=CC=1C1C2C=C(N[C:20](NCCO)=[O:21])C=CC=2N2C=NN=C2CN=1.[NH2:29][C:30]1[CH:31]=[CH:32][C:33]2[N:39]3[C:40]([CH3:43])=[N:41][N:42]=[C:38]3[CH2:37][N:36]=[C:35]([C:44]3[CH:49]=[CH:48][CH:47]=[CH:46][C:45]=3[Cl:50])[C:34]=2[CH:51]=1>C(Cl)Cl>[Cl:50][C:45]1[CH:46]=[CH:47][CH:48]=[CH:49][C:44]=1[C:35]1[C:34]2[CH:51]=[C:30]([N:29]=[C:20]=[O:21])[CH:31]=[CH:32][C:33]=2[N:39]2[C:40]([CH3:43])=[N:41][N:42]=[C:38]2[CH2:37][N:36]=1

Participants

4

Reactant 2

HCID 125625156-(2-Chlorophenyl)-1-methyl-4H-[1,2,4]triazolo[4,3-a][1,4]benzodiazepin-8-amineHCID 20508545HCID 20508545, compound

Product 1

HCID 20508562HCID 20508562, compound

Reagents, catalysts & solvents 1

HCID 6344DichloromethaneSolvent

Procedure

A solution of [6-(o-chlorophenyl)-1-methyl-4H-s-triazolo[4,3-a][1,4]benzodiazepin-8-yl]isocyanate is prepared as described in paragraph (a) of Example 1 from 7.0 g (21.6 mmol) of 8-amino-6-(o-chlorophenyl)-1-methyl-4H-s-triazolo[4,3-a][1,4]benzodiazepine, but using methylene chloride in place of 1,2-dichloroethane.

Sources & evidence

ORD record
ord-eadfb344159a489cae91c2b254017287
Source dataset
uspto-grants-1983_02
Patent number
US04374773

Reaction notes

Loading…