Acetic Acid → HCID 20508947, compound

Participants

Reaction Steps

A mixture of 0.01 mol of 4-(2-thienyl)imidazo[1,5-a]pyrimidine-8-carbonitrile (Example 1), 15 ml. of glacial acetic acid and 15 ml. of concentrated hydrochloric acid can be refluxed for 16 hours. The reaction mixture can be cooled and evaporated to dryness in vacuo, water added, and the precipitated solid recovered by filtration to produce 4-(2-thienyl)imidazo[1,5-a]pyrimidine-8-carboxylic acid.

Provenance & Evidence