Acetic Acid → HCID 20508947, compound

HRID 1758798Notes

Reaction equation

HRID 1758798 reaction equation
[S:1]1[CH:5]=[CH:4][CH:3]=[C:2]1[C:6]1[N:11]2[CH:12]=[N:13]C(C#N)=[C:10]2[N:9]=[CH:8][CH:7]=1.Cl.[C:18]([OH:21])(=[O:20])[CH3:19]>>[S:1]1[CH:5]=[CH:4][CH:3]=[C:2]1[C:6]1[N:11]2[CH:12]=[N:13][C:19]([C:18]([OH:21])=[O:20])=[C:10]2[N:9]=[CH:8][CH:7]=1

Participants

4

Reactant 3

HCID 176Acetic AcidHCID 313Hydrochloric AcidHCID 13117356HCID 13117356, compound

Product 1

HCID 20508947HCID 20508947, compound

Procedure

A mixture of 0.01 mol of 4-(2-thienyl)imidazo[1,5-a]pyrimidine-8-carbonitrile (Example 1), 15 ml. of glacial acetic acid and 15 ml. of concentrated hydrochloric acid can be refluxed for 16 hours. The reaction mixture can be cooled and evaporated to dryness in vacuo, water added, and the precipitated solid recovered by filtration to produce 4-(2-thienyl)imidazo[1,5-a]pyrimidine-8-carboxylic acid.

Workup

  1. temperatureThe reaction mixture can be cooled
  2. customevaporated to dryness in vacuo, water
  3. additionadded
  4. filtrationthe precipitated solid recovered by filtration

Sources & evidence

ORD record
ord-a62f8caa0b124dcc89305abe206d5539
Source dataset
uspto-grants-1983_02
Patent number
US04374988

Reaction notes

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