Trifluoroacetic acid → HCID 13130823, compound

HRID 1758805Notes

Reaction equation

[Cl:1][C:2]1[CH:22]=[CH:21][C:5]([C:6]([C:8]2[NH:12][C:11]([CH2:13][C:14]([OH:16])=[O:15])=[C:10](C(O)=O)[C:9]=2[CH3:20])=[O:7])=[CH:4][CH:3]=1.FC(F)(F)C(O)=O>>[Cl:1][C:2]1[CH:22]=[CH:21][C:5]([C:6]([C:8]2[NH:12][C:11]([CH2:13][C:14]([OH:16])=[O:15])=[CH:10][C:9]=2[CH3:20])=[O:7])=[CH:4][CH:3]=1

Participants

Reactant 2

HCID 6422Trifluoroacetic acid

HCID 18424159HCID 18424159, compound

Product 1

HCID 13130823HCID 13130823, compound

Procedure

The acidic decarboxylation is conducted under mild conditions. For example, 5-(p-chlorobenzoyl)-3-hydroxycarbonyl-4-methylpyrrole-2-acetic acid is treated with refluxing trifluoroacetic acid to afford 5-(p-chlorobenzoyl)-4-methylpyrrole-2-acetic acid. Other acids may also be used. For example, those listed below in Table I.

Sources & evidence

ORD record: ord-8beb921bd59d4293a2050f247c296cb1
Source dataset: uspto-grants-1983_02
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US04374997

Reaction notes

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