L-Alanyl-L-proline → HCID 44317085, compound

HRID 1758844Notes

Reaction equation

HRID 1758844 reaction equation
O=[C:2]([CH2:6][CH2:7][C:8]1[CH:13]=[CH:12][CH:11]=[CH:10][CH:9]=1)[C:3]([NH2:5])=[O:4].[NH2:14][C@H:15]([C:17]([N:19]1[CH2:26][CH2:25][CH2:24][C@H:20]1[C:21]([OH:23])=[O:22])=[O:18])[CH3:16].C([BH3-])#N.[Na+]>>[NH2:5][C:3]([CH:2]([NH:14][C@H:15]([C:17]([N:19]1[CH2:26][CH2:25][CH2:24][C@H:20]1[C:21]([OH:23])=[O:22])=[O:18])[CH3:16])[CH2:6][CH2:7][C:8]1[CH:13]=[CH:12][CH:11]=[CH:10][CH:9]=1)=[O:4]

Participants

4

Reactant 3

HCID 83525L-Alanyl-L-prolineHCID 5003444Sodium cyanoborohydrideHCID 18964887HCID 18964887, compound

Product 1

HCID 44317085HCID 44317085, compound

Procedure

In the manner described in example 26, one can condense 2-oxo-4-phenylbutyramide and L-alanyl-L-proline in the presence of sodium cyanoborohydride to yield N-(1-amino carbonyl-3-phenylpropyl)-L-alanyl-L-proline.

Sources & evidence

ORD record
ord-253009371c594c4a92c6733e8e00c177
Source dataset
uspto-grants-1983_02
Patent number
US04374829

Reaction notes

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