HuagongsheHuagongshe Chemistry Print Report · For research reference only
2-Oxo-4-phenylbutyric acid → N-(1-carboxy-3-phenylpropyl)-L-alanyl-L-proline amide
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 2-Oxo-4-phenylbutyric acid | HCID 69732 | — |
| Reactant | Sodium cyanoborohydride | HCID 5003444 | — |
| Reactant | (2S)-1-[(2S)-2-aminopropanoyl]pyrrolidine-2-carboxamide | HCID 11902966 | — |
| Solvent | Water ethanol | HCID 19096565 | — |
| Product | N-(1-carboxy-3-phenylpropyl)-L-alanyl-L-proline amide | HCID 54134361 | — |
Reaction Steps
Couple L-alanyl-L-proline amide, prepared as in Example 51, with 2-oxo-4-phenylbutyric acid employing sodium cyanoborohydride in 50% ethanol-water by the method described in example 2. After eluting from the ion-exchange resin, concentrate in vacuo to a small volume, flush with water, and freeze-dry to obtain N-(1-carboxy-3-phenylpropyl)-L-alanyl-L-proline amide as a mixture of diastereoisomers.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US04374829 |
| Source dataset | uspto-grants-1983_02 |
| ORD ID | ord-084b07114f954c47ac077e5ce64d4d5b |
| Source note | uspto-grants-1983_02 |