2-Amino-5-(trifluoromethyl)pyridine → 1-(2-Chloro-6-fluorobenzoyl)-3-(5-trifluoromethyl-2-pyridinyl)urea

HRID 1758926Notes

Reaction equation

HRID 1758926 reaction equation
[F:1][C:2]([F:11])([F:10])[C:3]1[CH:4]=[CH:5][C:6]([NH2:9])=[N:7][CH:8]=1.[Cl:12][C:13]1[CH:23]=[CH:22][CH:21]=[C:20]([F:24])[C:14]=1[C:15]([N:17]=[C:18]=[O:19])=[O:16]>>[Cl:12][C:13]1[CH:23]=[CH:22][CH:21]=[C:20]([F:24])[C:14]=1[C:15]([NH:17][C:18]([NH:9][C:6]1[CH:5]=[CH:4][C:3]([C:2]([F:1])([F:10])[F:11])=[CH:8][N:7]=1)=[O:19])=[O:16]

Participants

3

Reactant 2

HCID 7358622-Amino-5-(trifluoromethyl)pyridineHCID 130517312-Chloro-6-fluorobenzoyl isocyanate

Product 1

HCID 205331381-(2-Chloro-6-fluorobenzoyl)-3-(5-trifluoromethyl-2-pyridinyl)urea

Procedure

A portion of 5-trifluoromethyl-2-aminopyridine is reacted with 2-chloro-6-fluorobenzoyl isocyanate as described in Example 1. The reaction mixture is evaporated under vacuum and the product is recrystallized to obtain the product named above.

Workup

  1. customThe reaction mixture is evaporated under vacuum
  2. customthe product is recrystallized
  3. customto obtain the product

Sources & evidence

ORD record
ord-b8eb3f1f637c4e79a5ec9277707eb4d3
Source dataset
uspto-grants-1982_07
Patent number
US04338321

Reaction notes

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