2-Amino-5-(trifluoromethyl)pyridine → 1-(2,6-Difluorobenzoyl)-3-(5-trifluoromethyl-2-pyridinyl)urea

HRID 1758933Notes

Reaction equation

HRID 1758933 reaction equation
[F:1][C:2]([F:11])([F:10])[C:3]1[CH:4]=[CH:5][C:6]([NH2:9])=[N:7][CH:8]=1.[F:12][C:13]1[CH:33]=[CH:32][CH:31]=[C:30]([F:34])[C:14]=1[C:15]([NH:17][C:18](OC1C=CC([N+]([O-])=O)=CC=1)=[O:19])=[O:16]>>[F:12][C:13]1[CH:33]=[CH:32][CH:31]=[C:30]([F:34])[C:14]=1[C:15]([NH:17][C:18]([NH:9][C:6]1[CH:5]=[CH:4][C:3]([C:2]([F:1])([F:10])[F:11])=[CH:8][N:7]=1)=[O:19])=[O:16]

Participants

3

Reactant 2

HCID 7358622-Amino-5-(trifluoromethyl)pyridineHCID 572860812,6-Difluorobenzamidocarboxylic acid, 4-nitrophenyl ester

Product 1

HCID 128006031-(2,6-Difluorobenzoyl)-3-(5-trifluoromethyl-2-pyridinyl)urea

Procedure

A portion of 5-trifluoromethyl-2-aminopyridine is dissolved in an inert organic solvent, and to the solution is added a portion of 2,6-difluorobenzamidocarboxylic acid, 4-nitrophenyl ester. The reaction mixture is stirred at elevated temperature for a period of time, after which the reaction mixture is evaporated to dryness under vacuum, and the product named in the heading above, identical to the product of Example 1, is isolated by recrystallization.

Workup

  1. customafter which the reaction mixture is evaporated to dryness under vacuum
  2. customis isolated by recrystallization

Sources & evidence

ORD record
ord-a93812149305465286f526334053113d
Source dataset
uspto-grants-1982_07
Patent number
US04338321

Reaction notes

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