2-Amino-5-chloropyridine → Benzamide, 2-chloro-N-(((5-chloro-2-pyridinyl)amino)carbonyl)-6-fluoro-

HRID 1758935Notes

Reaction equation

HRID 1758935 reaction equation
[Cl:1][C:2]1[CH:22]=[CH:21][CH:20]=[C:19]([F:23])[C:3]=1[C:4]([NH:6][C:7]([O:9]C1C=CC([N+]([O-])=O)=CC=1)=O)=[O:5].[Cl:24][C:25]1[CH:26]=[CH:27][C:28]([NH2:31])=[N:29][CH:30]=1>>[Cl:1][C:2]1[CH:22]=[CH:21][CH:20]=[C:19]([F:23])[C:3]=1[C:4]([NH:6][C:7]([NH:31][C:28]1[CH:27]=[CH:26][C:25]([Cl:24])=[CH:30][N:29]=1)=[O:9])=[O:5]

Participants

3

Reactant 2

HCID 661742-Amino-5-chloropyridineHCID 570409802-Chloro-6-fluorobenzamidocarboxylic acid, 4-nitrophenyl ester

Product 1

HCID 174171Benzamide, 2-chloro-N-(((5-chloro-2-pyridinyl)amino)carbonyl)-6-fluoro-

Procedure

A portion of 2-chloro-6-fluorobenzamidocarboxylic acid, 4-nitrophenyl ester, is combined with a portion of 5-chloro-2-aminopyridine in an inert organic solvent. The reaction mixture is stirred at elevated temperature for a period of time, and is then evaporated under vacuum. The product named in the heading above, identical to the product of Example 3, is isolated by recrystallization.

Workup

  1. customis then evaporated under vacuum
  2. customis isolated by recrystallization

Sources & evidence

ORD record
ord-164a28f86ca041688b417f355327a521
Source dataset
uspto-grants-1982_07
Patent number
US04338321

Reaction notes

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