Hydrochloric Acid → 5-Carbamoyl-1-(2,6-dimethylphenyl)uracil

HRID 1758953Notes

Reaction equation

HRID 1758953 reaction equation
[C:1]([C:3]1[C:4](=[O:18])[NH:5][C:6](=[O:17])[N:7]([C:9]2[C:14]([CH3:15])=[CH:13][CH:12]=[CH:11][C:10]=2[CH3:16])[CH:8]=1)#[N:2].Cl.[OH-:20].[Na+]>>[C:1]([C:3]1[C:4](=[O:18])[NH:5][C:6](=[O:17])[N:7]([C:9]2[C:14]([CH3:15])=[CH:13][CH:12]=[CH:11][C:10]=2[CH3:16])[CH:8]=1)(=[O:20])[NH2:2]

Participants

4

Reactant 3

HCID 313Hydrochloric AcidHCID 14798Sodium HydroxideHCID 13014421HCID 13014421, compound

Product 1

HCID 130144985-Carbamoyl-1-(2,6-dimethylphenyl)uracil

Procedure

A mixture of 5-cyano-1-(2,6-dimethylphenyl)uracil (0.01 mol) and 50 ml of NaOH (2.5 N) is heated for 2 hours at about 90°. After cooling, a small amount of dilute HCl is added to precipitate product. The mixture is filtered to the collected precipitate washed with water to yield 5-carbamoyl-1-(2,6-dimethylphenyl)uracil.

Workup

  1. temperatureis heated for 2 hours at about 90°
  2. temperatureAfter cooling
  3. customto precipitate product
  4. filtrationThe mixture is filtered to the collected precipitate
  5. washwashed with water

Sources & evidence

ORD record
ord-24d5c91d4aa9442186189545f4b0a719
Source dataset
uspto-grants-1982_07
Patent number
US04338318

Reaction notes

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