2-Amino-1-(3-chlorophenyl)ethan-1-ol → Brl 35135

HRID 1758979Notes

Reaction equation

HRID 1758979 reaction equation
[C:1]([CH2:5][O:6][C:7]1[CH:12]=[CH:11][C:10]([CH2:13][C:14](=O)[CH3:15])=[CH:9][CH:8]=1)([O:3][CH3:4])=[O:2].[OH:17][CH:18]([C:21]1[CH:26]=[CH:25][CH:24]=[C:23]([Cl:27])[CH:22]=1)[CH2:19][NH2:20]>>[C:1]([CH2:5][O:6][C:7]1[CH:12]=[CH:11][C:10]([CH2:13][CH:14]([NH:20][CH2:19][CH:18]([OH:17])[C:21]2[CH:26]=[CH:25][CH:24]=[C:23]([Cl:27])[CH:22]=2)[CH3:15])=[CH:9][CH:8]=1)([O:3][CH3:4])=[O:2]

Participants

3

Reactant 2

HCID 37516012-Amino-1-(3-chlorophenyl)ethan-1-olHCID 13851156Methyl 2-(4-(2-oxopropyl)phenoxy)acetate

Product 1

HCID 122186Brl 35135

Procedure

The compound was prepared as in Example 5 from 1-(4-carbomethoxymethoxyphenyl)propan-2-one (2.22 g) and 2-hydroxy-2-(3-chlorophenyl) ethanamine (1.71 g) and crystallised from hexane m.p. 82°-87° as a 58:42 mixture of diastereoisomers.

Workup

  1. customcrystallised from hexane m.p. 82°-87° as a 58:42 mixture of diastereoisomers

Sources & evidence

ORD record
ord-e6fd09130ebc493e843ee4440ed1af39
Source dataset
uspto-grants-1982_07
Patent number
US04338333

Reaction notes

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