Phenylethanolamine → HCID 20533256, compound

HRID 1758980Notes

Reaction equation

HRID 1758980 reaction equation
[C:1]([CH2:5][O:6][C:7]1[CH:12]=[CH:11][C:10]([CH2:13][C:14](=O)[CH3:15])=[CH:9][CH:8]=1)([O:3][CH3:4])=[O:2].[OH:17][CH:18]([C:21]1[CH:26]=[CH:25][CH:24]=[CH:23][CH:22]=1)[CH2:19][NH2:20]>>[C:1]([CH2:5][O:6][C:7]1[CH:12]=[CH:11][C:10]([CH2:13][CH:14]([NH:20][CH2:19][CH:18]([OH:17])[C:21]2[CH:26]=[CH:25][CH:24]=[CH:23][CH:22]=2)[CH3:15])=[CH:9][CH:8]=1)([O:3][CH3:4])=[O:2]

Participants

3

Reactant 2

HCID 1000PhenylethanolamineHCID 13851156Methyl 2-(4-(2-oxopropyl)phenoxy)acetate

Product 1

HCID 20533256HCID 20533256, compound

Procedure

The compound was prepared as in Example 1 from 1-(4-carbomethoxymethoxyphenyl)propan-2-one (4.1 g) and 2-hydroxy-2-phenylethylamine (2.53 g). The compound was purified initially by column chromatography on silica gel and crystallised as the hydrobromide salt from methanol/diethyl ether m.p. 147°-160° as a 90:10 mixture of diastereoisomers.

Workup

  1. customThe compound was purified initially by column chromatography on silica gel
  2. customcrystallised as the hydrobromide salt from methanol/diethyl ether m.p. 147°-160° as a 90:10 mixture of diastereoisomers

Sources & evidence

ORD record
ord-9e3c2600634e46c8828858ec16f1ba63
Source dataset
uspto-grants-1982_07
Patent number
US04338333

Reaction notes

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