Methylamine → HCID 178485069, compound

HRID 1759004Notes

Reaction equation

HRID 1759004 reaction equation
[C:1]([N:3]=[C:4](SC)[NH:5][CH2:6][CH2:7][S:8][CH2:9][C:10]1[N:14]=[C:13]([NH:15][C:16]([NH2:18])=[NH:17])[O:12][N:11]=1)#[N:2].[CH3:21][NH2:22]>C(O)C>[C:1]([N:3]=[C:4]([NH:22][CH3:21])[NH:5][CH2:6][CH2:7][S:8][CH2:9][C:10]1[N:14]=[C:13]([NH:15][C:16]([NH2:18])=[NH:17])[O:12][N:11]=1)#[N:2]

Participants

4

Reactant 2

HCID 6329MethylamineHCID 178503929HCID 178503929, compound

Product 1

HCID 178485069HCID 178485069, compound

Reagents, catalysts & solvents 1

HCID 702EthanolSolvent2×

Procedure

To a solution of 3-[2-(3-cyano-2-methyl-isothioureido)ethylthiomethyl]-5-guanidino-1,2,4-oxadiazole (0.7 g.) in ethanol (20 ml.) was added a 33% w/v solution of methylamine in ethanol (30 ml.) The solution was kept for 18 hours at 20°, evaporated in vacuo and the residue finally dried at 30°/0.05 mm. to give 3-[2-(2-cyano-3-methylguanidino)ethylthiomethyl]-5-guanidino-1,2,4-oxadiazole as a white solid, m.p. 185°-188°.

Workup

  1. customevaporated in vacuo
  2. customthe residue finally dried at 30°/0.05 mm

Sources & evidence

ORD record
ord-0e94987d0ba9467ab336d276d2f5584a
Source dataset
uspto-grants-1982_07
Patent number
US04338448

Reaction notes

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