Hydrochloric Acid → HCID 13388351, compound

HRID 1759055Notes

Reaction equation

HRID 1759055 reaction equation
[CH3:1][C:2]1[NH:3][C:4]([CH:25](OCC)[O:26]CC)=[C:5]([C:20]([O:22][CH2:23][CH3:24])=[O:21])[CH:6]([C:13]2[CH:18]=[CH:17][CH:16]=[CH:15][C:14]=2[Cl:19])[C:7]=1[C:8]([O:10][CH2:11][CH3:12])=[O:9].Cl>CC(C)=O>[CH3:1][C:2]1[NH:3][C:4]([CH:25]=[O:26])=[C:5]([C:20]([O:22][CH2:23][CH3:24])=[O:21])[CH:6]([C:13]2[CH:18]=[CH:17][CH:16]=[CH:15][C:14]=2[Cl:19])[C:7]=1[C:8]([O:10][CH2:11][CH3:12])=[O:9]

Participants

4

Reactant 2

HCID 313Hydrochloric AcidHCID 13469459HCID 13469459, compound

Product 1

HCID 13388351HCID 13388351, compound

Reagents, catalysts & solvents 1

HCID 180AcetoneSolvent

Procedure

To a solution of diethyl 2-methyl-4-(2-chlorophenyl)-6-diethoxymethyl-1,4-dihydropyridine-3,5-dicarboxylate (452 mg) in acetone (5 ml) was added 6N-hydrochloric acid (0.2 to 0.3 ml) and stirred at room temperature for an hour. After removing acetone, the residue was extracted with ethyl acetate twice and the extract was washed with water and dried. The solvent was removed from the extract to give diethyl 2-methyl-4-(2-chlorophenyl)-6-formyl-1,4-dihydropyridine-3,5-dicarboxylate. The product was recrystallized from a mixture of n-hexane and diethyl ether to give the pure product, m.p. 87° to 88° C.

Workup

  1. customAfter removing acetone
  2. extractionthe residue was extracted with ethyl acetate twice
  3. washthe extract was washed with water
  4. customdried
  5. customThe solvent was removed from the
  6. extractionextract

Sources & evidence

ORD record
ord-348b06c6bbda43e9941a7ac6b0e3fffc
Source dataset
uspto-grants-1982_07
Patent number
US04338322

Reaction notes

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