Acetic Anhydride → HCID 70073884, compound

HRID 1759074Notes

Reaction equation

HRID 1759074 reaction equation
[CH3:1][C:2]1[NH:3][C:4]([CH:34]=O)=C(C(OCC)=O)[CH:6]([C:20]2[CH:25]=[CH:24][CH:23]=[CH:22][C:21]=2[N+:26]([O-:28])=[O:27])[C:7]=1[C:8]([O:10][CH2:11][CH2:12][O:13][C:14]1[CH:19]=[CH:18][CH:17]=[CH:16][CH:15]=1)=[O:9].Cl.[NH2:37]O.C([O-])(=O)C.[Na+].[C:44]([O:47][C:48](=O)[CH3:49])(=[O:46])[CH3:45]>C(O)(=O)C>[CH3:1][C:2]1[NH:3][C:4]([C:34]#[N:37])=[C:45]([C:44]([O:47][CH2:48][CH3:49])=[O:46])[CH:6]([C:20]2[CH:25]=[CH:24][CH:23]=[CH:22][C:21]=2[N+:26]([O-:28])=[O:27])[C:7]=1[C:8]([O:10][CH2:11][CH2:12][O:13][C:14]1[CH:15]=[CH:16][CH:17]=[CH:18][CH:19]=1)=[O:9]

Participants

6

Reactant 4

HCID 7918Acetic AnhydrideHCID 443297Hydroxyamine hydrochlorideHCID 517045Sodium AcetateHCID 21328040HCID 21328040, compound

Product 1

HCID 70073884HCID 70073884, compound

Reagents, catalysts & solvents 1

HCID 176Acetic AcidSolvent

Procedure

Starting from a mixture of 2-phenoxyethyl 2-methyl-4-(2-nitrophenyl)-5-ethoxycarbonyl-6-formyl-1,4-dihydropyridine-3-carboxylate (1.03 g), hydroxylamine hydrochloride (178.6 mg) and sodium acetate (352 mg) in acetic acid (8 ml) and acetic anhydride (1 ml), there was obtained in a similar manner to that of Example 4-2) an oil (420 mg) of 2-phenoxyethyl 2-methyl-4-(2-nitrophenyl)-5-ethoxycarbonyl-6-cyano-1,4-dihydropyridine-3-carboxylate.

Sources & evidence

ORD record
ord-da6db372f568430f9d764172daf3fc3a
Source dataset
uspto-grants-1982_07
Patent number
US04338322

Reaction notes

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