反应详情

To a dry, stirred solution of 7.5 g of 6,7-dihydro-4-methyl-5H-cyclopentapyrimidin-2-amine in 200 ml of methylene chloride at ambient temperature and pressure is added 13 g of 2-chloropyrimidine-3-sulfonylisocyanate. The resulting mixture is stirred at reflux for 2 hours and then concentrated at reduced pressure. The residue is triturated with 1-chlorobutane and filtered to yield the desired solid product.

1. temperatureat reflux for 2 hours
2. concentrationconcentrated at reduced pressure
3. customThe residue is triturated with 1-chlorobutane
4. filtrationfiltered
5. customto yield the desired solid product