HuagongsheHuagongshe Chemistry Print Report · For research reference only
Dichloromethane → 2-Chloro-N-[(6,7-dihydro-4-methyl-5H-cyclopentapyrimidin-2-yl)aminocarbonyl]pyridine-3-sulfonamide
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Dichloromethane | HCID 6344 | — |
| Reactant | 4-Methyl-6,7-dihydro-5H-cyclopenta[d]pyrimidin-2-amine | HCID 904212 | — |
| Reactant | 2-Chloropyrimidine-3-sulfonylisocyanate | HCID 20532143 | — |
| Product | 2-Chloro-N-[(6,7-dihydro-4-methyl-5H-cyclopentapyrimidin-2-yl)aminocarbonyl]pyridine-3-sulfonamide | HCID 20532149 | — |
Reaction Steps
To a dry, stirred solution of 7.5 g of 6,7-dihydro-4-methyl-5H-cyclopentapyrimidin-2-amine in 200 ml of methylene chloride at ambient temperature and pressure is added 13 g of 2-chloropyrimidine-3-sulfonylisocyanate. The resulting mixture is stirred at reflux for 2 hours and then concentrated at reduced pressure. The residue is triturated with 1-chlorobutane and filtered to yield the desired solid product.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US04339267 |
| Source dataset | uspto-grants-1982_07 |
| ORD ID | ord-daf8c73518e1433d888d201b692a4462 |
| Source note | uspto-grants-1982_07 |