Ammonia → HCID 19964218, compound

52 g (500 mmoles) of sodium bisulfite are dissolved in 250 ml of warm water, 53.6 ml (510 mmoles) of n-valeraldehyde are added, and the resulting orange-red mixture is stirred on a steam bath until it turns colorless. The solution is cooled to room temperature, 400 ml of concentrated aqueous ammonia are added, the mixture is stirred at room temperature for one hour, and then allowed to stand in a refrigerator overnight. The reaction mixture is washed with 100 ml of diethyl ether, decolourized with carbon, filtered, and the pH of the filtrate is adjusted to 3 with concentrated aqueous hydrochloric acid under cooling. The separated crystalline substance is filtered off, washed with water and diethyl ether, and dried in a vacuum desiccator. 47.6 g (56.8%) of DL-α-aminopentanesulfonic acid are obtained; m.p.: 142° C., Rf9 =0.3-0.4.

1. stirringthe mixture is stirred at room temperature for one hour
2. customto stand in a refrigerator overnight
3. washThe reaction mixture is washed with 100 ml of diethyl ether
4. filtrationfiltered
5. temperatureunder cooling
6. filtrationThe separated crystalline substance is filtered off
7. washwashed with water and diethyl ether
8. customdried in a vacuum desiccator

ORD record

ord-1fb47204f8274192822f443f40e32db2

Source dataset

uspto-grants-1982_07

DOI

10.6084/m9.figshare.5104873.v1

Patent number

US04339440