HCID 12803422, compound → 1-(2-Methoxyethyl)-4-phenylimidazolidin-2-one

HRID 1759261Notes

Reaction equation

HRID 1759261 reaction equation
[CH3:1][O:2][CH2:3][CH2:4][N:5]1[CH:9]=[C:8]([C:10]2[CH:15]=[CH:14][CH:13]=[CH:12][CH:11]=2)[NH:7][C:6]1=[O:16]>[Pd].C(O)C>[CH3:1][O:2][CH2:3][CH2:4][N:5]1[CH2:9][CH:8]([C:10]2[CH:15]=[CH:14][CH:13]=[CH:12][CH:11]=2)[NH:7][C:6]1=[O:16]

Participants

4

Reactant 1

HCID 12803422HCID 12803422, compound

Product 1

HCID 128034231-(2-Methoxyethyl)-4-phenylimidazolidin-2-oneYield 91.5%

Reagents, catalysts & solvents 2

HCID 23938PalladiumCatalystHCID 702EthanolSolvent

Procedure

The 1-(2-methoxyethyl)-4-phenyl-4-imidazolin-2-one (6.5 g) so obtained is next admixed with 10% palladium on carbon (0.7 g) in ethanol (50 ml). The mixture is thereafter hydrogenated at 50 psi at room temperature for four hours and the catalyst is filtered. Resultant filtrate is finally concentrated to yield racemic 1-(2-methoxyethyl)-4-phenyl-2-imidazolidone (6.0 g), [α]D20 =-0.2(c=1 in CHCl3).

Workup

  1. filtrationthe catalyst is filtered
  2. concentrationResultant filtrate is finally concentrated

Sources & evidence

ORD record
ord-7cec78dbd0884ea285c883ff0da02de3
Source dataset
uspto-grants-1982_07
Patent number
US04339603

Reaction notes

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