Ammonium Hydroxide → HCID 54033597, compound

HRID 1759269Notes

Reaction equation

HRID 1759269 reaction equation
[OH:1][C:2]1[CH:3]=[C:4]([CH:19]=[CH:20][C:21]=1[OH:22])[CH2:5][C@@H:6]([C:16]([OH:18])=[O:17])[NH:7][C:8](=[O:15])[CH2:9][CH2:10][S:11]C(=O)C.[OH-].[NH4+]>>[OH:1][C:2]1[CH:3]=[C:4]([CH:19]=[CH:20][C:21]=1[OH:22])[CH2:5][C@@H:6]([C:16]([OH:18])=[O:17])[NH:7][C:8](=[O:15])[CH2:9][CH2:10][SH:11]

Participants

3

Reactant 2

HCID 14923Ammonium HydroxideHCID 88752991HCID 88752991, compound

Product 1

HCID 54033597HCID 54033597, compound

Procedure

3-Hydroxy-N-(3-acetylthiopropanoyl)-L-tyrosine (280 mg.) is treated with concentrated ammonium hydroxide according to the procedure in Example 76. The crude product, 3-hydroxy-N-(3-Mercaptopropanoyl)-L-tyrosine is crystallized from acetonitrile, yield 157 mg., m.p. 89°-91°.

Workup

  1. customThe crude product, 3-hydroxy-N-(3-Mercaptopropanoyl)-L-tyrosine is crystallized from acetonitrile, yield 157 mg

Sources & evidence

ORD record
ord-cbf93a94457945c883421a336aa79dc6
Source dataset
uspto-grants-1982_07
Patent number
US04339600

Reaction notes

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