Triethylamine → HCID 178433293, compound

HRID 1759357Notes

Reaction equation

HRID 1759357 reaction equation
[CH:1]1[N:6]=[C:5](Cl)[C:4]2[N:8]=[CH:9][N:10]([C@@H:11]3[O:15][C@H:14]([CH2:16][OH:17])[C@@H:13]([OH:18])[C@H:12]3[OH:19])[C:3]=2[N:2]=1.[CH3:20][C:21]1[N:22]=[CH:23][NH:24][C:25]=1[CH2:26][S:27][CH2:28][CH2:29][NH2:30].C(N(CC)CC)C>C(O)C>[CH3:20][C:21]1[N:22]=[CH:23][NH:24][C:25]=1[CH2:26][S:27][CH2:28][CH2:29][NH:30][C:5]1[C:4]2[N:8]=[CH:9][N:10]([C:3]=2[N:2]=[CH:1][N:6]=1)[C@@H:11]1[O:15][C@H:14]([CH2:16][OH:17])[C@@H:13]([OH:18])[C@H:12]1[OH:19]

Participants

5

Reactant 3

HCID 8471TriethylamineHCID 930036-Chloropurine ribosideHCID 178433288HCID 178433288, compound

Product 1

HCID 178433293HCID 178433293, compound

Reagents, catalysts & solvents 1

HCID 702EthanolSolvent

Procedure

5.0 g of 6-chloropurine riboside (0.0179 moles) 4.6 g of 4-methyl-5-[(2 aminoethyl)-thiomethyl]-imidazole (0.019 moles), and 8.78 ml of triethylamine (0.063 moles) are refluxed overnight in 100 ml of ethanol. 15 ml of solvent are then removed with nitrogen gas. The crystals formed therefrom are filtered and washed with ethanol. The crystals are then recrystallized from ethanol and washed with diethyl ether.

Workup

  1. custom15 ml of solvent are then removed with nitrogen gas
  2. customThe crystals formed
  3. filtrationtherefrom are filtered
  4. washwashed with ethanol
  5. customThe crystals are then recrystallized from ethanol
  6. washwashed with diethyl ether

Sources & evidence

ORD record
ord-c0ba066a78444e418022ee2fe0cf507d
Source dataset
uspto-grants-1982_07
Patent number
US04340730

Reaction notes

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