反应详情

2.5 g of 1-(5-deoxy-2,3-di-O-acetyl-β-D-ribofuranosyl)-5-fluorouracil were heated under reflux in 60 ml of methanol in the presence of 0.3 ml of triethylamine until starting material could no longer be detected by thin-layer chromatography. The colourless, clear solution was concentrated under reduced pressure and the white, crystalline material obtained was recrystallised from water. There was obtained pure 5'-deoxy-5-fluorouridine, m.p. 192°-193° C., in 98% yield.

1. concentrationThe colourless, clear solution was concentrated under reduced pressure
2. customthe white, crystalline material obtained
3. customwas recrystallised from water