反应详情

To a stirred and refluxing mixture of 11.2 parts of iron, 100 parts of ammonium chloride solution 0.8 N and 20 parts of methylbenzene are added 10.5 parts of (4-chloro-3-nitrophenyl)phenylmethanone and the whole is further stirred at reflux temperature for one hour. Methylbenzene (80 parts) is added and the whole is filtered over Hyflo. The organic layer is separated, dried, filtered and evaporated. The residue is washed with cyclohexane, yielding 8.4 parts of (3-amino-4-chlorophenyl)phenylmethanone; mp. 91.9° C.

1. temperaturerefluxing
2. stirringthe whole is further stirred
3. temperatureat reflux temperature for one hour
4. filtrationthe whole is filtered over Hyflo
5. customThe organic layer is separated
6. customdried
7. filtrationfiltered
8. customevaporated
9. washThe residue is washed with cyclohexane