Acetic Acid → HCID 12873988, compound

HRID 1759410Notes

Reaction equation

HRID 1759410 reaction equation
[N:1]1[CH:2]=[CH:3][N:4]2[C:8]3[CH:9]=[C:10]([NH2:13])[CH:11]=[CH:12][C:7]=3[S:6][C:5]=12.C(O)(=O)C.[O-:18][C:19]#[N:20].[K+].[OH-].[NH4+]>O>[N:1]1[CH2:2][CH2:3][N:4]2[C:8]3[CH:9]=[C:10]([NH:13][C:19]([NH2:20])=[O:18])[CH:11]=[CH:12][C:7]=3[S:6][C:5]=12

Participants

6

Reactant 4

HCID 176Acetic AcidHCID 14923Ammonium HydroxideHCID 11378442Potassium cyanateHCID 20514572HCID 20514572, compound

Product 1

HCID 12873988HCID 12873988, compound

Reagents, catalysts & solvents 1

HCID 962WaterSolvent2×

Procedure

To a stirred mixture of 3 parts of imidazo[2,1-b]benzothiazol-6-amine, 16 parts of acetic acid and 32 parts of water is added dropwise a solution of 1.54 parts of potassium cyanate in 32 parts of water (slightly exothermic reaction). Upon completion, stirring is continued overnight at room temperature. The reaction mixture is alkalized with ammonium hydroxide. Upon stirring, the product is precipitated. It is filtered off and dried, yielding 3 parts of N-(2,3-dihydroimidazo[2,1-b]benzothiazol-6-yl)urea; mp. +300° C. Example XXXVII

Workup

  1. customslightly exothermic reaction)
  2. stirringUpon stirring
  3. customthe product is precipitated
  4. filtrationIt is filtered off
  5. customdried

Sources & evidence

ORD record
ord-7209a08d1c624b159e49256e354bc938
Source dataset
uspto-grants-1982_07
Patent number
US04340738

Reaction notes

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