beta-(p-Chlorophenyl)propionic acid → HCID 13022432, compound

Participants

Reaction Conditions

Reaction Steps

3-(4-Chlorophenyl)propionic acid (0.20 mole) and iron (hydrogen reduced, 0.11 mole) are heated for 1.5 hours at 195° C. under a nitrogen atmosphere. After that time, the temperature is increased to 290° C. and maintained at that temperature for 3 hours. The cooled reaction mass is extracted well with ether, filtered through Celite, and the ethereal extracts concentrated under vacuum. The residue is stripped under vacuum to leave the product.

Provenance & Evidence