beta-(p-Chlorophenyl)propionic acid → HCID 13022432, compound

HRID 1759457Notes

Reaction equation

HRID 1759457 reaction equation
[Cl:1][C:2]1[CH:7]=[CH:6][C:5]([CH2:8][CH2:9][C:10]([OH:12])=O)=[CH:4][CH:3]=1>[Fe]>[Cl:1][C:2]1[CH:7]=[CH:6][C:5]([CH2:8][CH2:9][C:10](=[O:12])[CH2:9][CH2:8][C:5]2[CH:4]=[CH:3][C:2]([Cl:1])=[CH:7][CH:6]=2)=[CH:4][CH:3]=1

Participants

3

Reactant 1

HCID 123137beta-(p-Chlorophenyl)propionic acid

Product 1

HCID 13022432HCID 13022432, compound

Reagents, catalysts & solvents 1

HCID 23925IronCatalyst

Conditions

Temperature
290 °C

Procedure

3-(4-Chlorophenyl)propionic acid (0.20 mole) and iron (hydrogen reduced, 0.11 mole) are heated for 1.5 hours at 195° C. under a nitrogen atmosphere. After that time, the temperature is increased to 290° C. and maintained at that temperature for 3 hours. The cooled reaction mass is extracted well with ether, filtered through Celite, and the ethereal extracts concentrated under vacuum. The residue is stripped under vacuum to leave the product.

Workup

  1. temperaturemaintained at that temperature for 3 hours
  2. customThe cooled reaction mass
  3. extractionis extracted well with ether
  4. filtrationfiltered through Celite
  5. concentrationthe ethereal extracts concentrated under vacuum
  6. customto leave the product

Sources & evidence

ORD record
ord-c285ad8e28bf4e8e92922cca53872d8e
Source dataset
uspto-grants-1982_07
Patent number
US04340756

Reaction notes

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