Benzoyl chloride → 3-Chloro-2,2,3-trifluoro-propionyl chloride

HRID 1759583Notes

Reaction equation

HRID 1759583 reaction equation
[Cl:1][CH:2]([F:9])[C:3]([F:8])([F:7])[C:4](O)=[O:5].C([Cl:18])(=O)C1C=CC=CC=1>>[Cl:1][CH:2]([F:9])[C:3]([F:8])([F:7])[C:4]([Cl:18])=[O:5]

Participants

3

Reactant 2

HCID 7412Benzoyl chlorideHCID 205313223-Chloro-2,2,3-trifluoropropanoic acid

Product 1

HCID 141224163-Chloro-2,2,3-trifluoro-propionyl chloride

Procedure

In a three-necked 2 l flask provided with a Vigreux column, a condenser, and a collecting flask were brought 325 g (2 moles) of 3-chloro-2,2,3-trifluoro-propionic acid (Org.Synth.Coll. 5, 239) and 562 g (4 moles) of benzoyl chloride. The mixture was heated so that the acid chloride distilled over slowly. The collected product was refluxed for 20 min to eliminate any residual hydrochloric acid. Finally the product was distilled at normal pressure. Yield: 280 g. Boiling point: 72°-74° C.

Workup

  1. customIn a three-necked 2 l flask provided with a Vigreux column, a condenser, and a collecting flask
  2. distillationdistilled over slowly
  3. temperatureThe collected product was refluxed for 20 min
  4. distillationFinally the product was distilled at normal pressure

Sources & evidence

ORD record
ord-c436943872e143dca8a6cbf920ea371e
Source dataset
uspto-grants-1982_07
Patent number
US04341864

Reaction notes

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