反应详情

In a three-necked 2 l flask provided with a Vigreux column, a condenser, and a collecting flask were brought 325 g (2 moles) of 3-chloro-2,2,3-trifluoro-propionic acid (Org.Synth.Coll. 5, 239) and 562 g (4 moles) of benzoyl chloride. The mixture was heated so that the acid chloride distilled over slowly. The collected product was refluxed for 20 min to eliminate any residual hydrochloric acid. Finally the product was distilled at normal pressure. Yield: 280 g. Boiling point: 72°-74° C.

1. customIn a three-necked 2 l flask provided with a Vigreux column, a condenser, and a collecting flask
2. distillationdistilled over slowly
3. temperatureThe collected product was refluxed for 20 min
4. distillationFinally the product was distilled at normal pressure