4-Hydroxypyrrolidine → HCID 12152136, compound

HRID 1759665Notes

Reaction equation

HRID 1759665 reaction equation
Cl[C:2]1[N:7]=[C:6]([O:8][CH3:9])[C:5]([N+:10]([O-:12])=[O:11])=[CH:4][CH:3]=1.[NH:13]1[CH2:17][CH2:16][CH:15]([OH:18])[CH2:14]1>C(O)C>[CH3:9][O:8][C:6]1[N:7]=[C:2]([N:13]2[CH2:17][CH2:16][CH:15]([OH:18])[CH2:14]2)[CH:3]=[CH:4][C:5]=1[N+:10]([O-:12])=[O:11]

Participants

4

Reactant 2

HCID 982104-HydroxypyrrolidineHCID 107977036-Chloro-2-methoxy-3-nitropyridine

Product 1

HCID 12152136HCID 12152136, compoundYield 78.9%

Reagents, catalysts & solvents 1

HCID 702EthanolSolvent

Procedure

2 g (0.0106 mol) of 6-chloro-2-methoxy-3-nitropyridine, 25 ml of ethanol and 1.9 g of 3-pyrrolidinol are charged to a fully equipped round-bottomed flask. The mixture is brought to 50° C. for one hour with stirring and the mixture is poured onto an ice/water mixture with stirring. The precipitate formed is filtered off and dried. 2 g of yellow powder are obtained.

Workup

  1. stirringwith stirring
  2. customThe precipitate formed
  3. filtrationis filtered off
  4. customdried

Sources & evidence

ORD record
ord-2ae9a172663d42a0b6e6f1b751aa9cc9
Source dataset
uspto-grants-2005_01
Patent number
US06837908B2

Reaction notes

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