HCID 12152140, compound → HCID 12091771, compound

HRID 1759668Notes

Reaction equation

HRID 1759668 reaction equation
[NH2:1][C:2]1[C:7]([N+:8]([O-])=O)=[CH:6][CH:5]=[C:4]([N:11]2[CH2:15][CH2:14][CH2:13][CH2:12]2)[N:3]=1>[Pd].C(O)C>[NH2:8][C:7]1[CH:6]=[CH:5][C:4]([N:11]2[CH2:15][CH2:14][CH2:13][CH2:12]2)=[N:3][C:2]=1[NH2:1]

Participants

4

Reactant 1

HCID 12152140HCID 12152140, compound

Product 1

HCID 12091771HCID 12091771, compoundYield 122.7%

Reagents, catalysts & solvents 2

HCID 23938PalladiumCatalystHCID 702EthanolSolvent

Procedure

2 g of 2-amino-3-nitro-6-(pyrrolidin-1-yl)pyridine, synthesized according to the above procedure, 100 ml of ethanol and 0.5 g of palladium-on-charcoal are charged to a 300 ml autoclave. The mixture is reduced for one hour at a pressure of 8 bar with stirring. The catalyst is subsequently removed by filtration and then the filtrate is acidified with hydrochloric acid. After diluting with diisopropyl ether, the precipitate formed is filtered off and dried. 2.1 g of powder are obtained, Yd=87.1%.

Workup

  1. additionare charged to a 300 ml autoclave
  2. customThe catalyst is subsequently removed by filtration
  3. additionAfter diluting with diisopropyl ether
  4. customthe precipitate formed
  5. filtrationis filtered off
  6. customdried

Sources & evidence

ORD record
ord-754680f1188a4dcfbaebcdbd7a3f8bb3
Source dataset
uspto-grants-2005_01
Patent number
US06837908B2

Reaction notes

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