HuagongsheHuagongshe Chemistry Print Report · For research reference only
1,4-Dioxane → HCID 12152141, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 1,4-Dioxane | HCID 31275 | — |
| Reactant | 4-Hydroxypyrrolidine | HCID 98210 | — |
| Reactant | 6-Chloro-3-nitropyridin-2-ylamine | HCID 2724035 | — |
| Solvent | Water | HCID 962 | — |
| Product | HCID 12152141 | HCID 12152141 | 87.7% |
Reaction Steps
2 g (0.012 mol) of 2-amino-6-chloro-3-nitropyridine, 30 ml of dioxane and 10 ml of water, and 1.8 g of 3-pyrrolidinol are charged to a fully equipped round-bottomed flask. The mixture is brought to 70° C. for one hour with stirring and then the mixture is poured onto an ice/water mixture with stirring. The precipitate formed is filtered off and dried. 2.36 g of yellow powder are obtained, Yd=87.4%.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US06837908B2 |
| Source dataset | uspto-grants-2005_01 |
| ORD ID | ord-792e211ae98747e3a8360c95c3314f02 |
| Source note | uspto-grants-2005_01 |