1,4-Dioxane → HCID 12152141, Verbindung

HRID 1759669Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 1759669
[NH2:1][C:2]1[C:7]([N+:8]([O-:10])=[O:9])=[CH:6][CH:5]=[C:4](Cl)[N:3]=1.O1CCOCC1.[NH:18]1[CH2:22][CH2:21][CH:20]([OH:23])[CH2:19]1>O>[NH2:1][C:2]1[N:3]=[C:4]([N:18]2[CH2:22][CH2:21][CH:20]([OH:23])[CH2:19]2)[CH:5]=[CH:6][C:7]=1[N+:8]([O-:10])=[O:9]

Komponenten

5

Edukt 3

HCID 312751,4-DioxaneHCID 982104-HydroxypyrrolidineHCID 27240356-Chloro-3-nitropyridin-2-ylamine

Produkt 1

HCID 12152141HCID 12152141, VerbindungAusbeute 87,7 %

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 962WaterLösungsmittel

Versuchsvorschrift

2 g (0.012 mol) of 2-amino-6-chloro-3-nitropyridine, 30 ml of dioxane and 10 ml of water, and 1.8 g of 3-pyrrolidinol are charged to a fully equipped round-bottomed flask. The mixture is brought to 70° C. for one hour with stirring and then the mixture is poured onto an ice/water mixture with stirring. The precipitate formed is filtered off and dried. 2.36 g of yellow powder are obtained, Yd=87.4%.

Aufarbeitung

  1. stirringwith stirring
  2. customThe precipitate formed
  3. filtrationis filtered off
  4. customdried

Quellen und Nachweise

ORD-Eintrag
ord-792e211ae98747e3a8360c95c3314f02
Quelldatensatz
uspto-grants-2005_01
Patentnummer
US06837908B2

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