1,4,5,6-Tetrahydropyrimidin-2-amine → HCID 86594977, compound

HRID 1759707Notes

Reaction equation

HRID 1759707 reaction equation
[S:1]1[C:5]2[CH:6]=[CH:7][CH:8]=[CH:9][C:4]=2[N:3]=[C:2]1[NH:10][C@H:11]([C:28]([O:30][C:31]([CH3:34])([CH3:33])[CH3:32])=[O:29])[CH2:12][C:13]1[CH:18]=[CH:17][C:16]([O:19][CH2:20][CH2:21][CH2:22][C:23]([O:25]CC)=O)=[CH:15][CH:14]=1.[NH2:35][C:36]1[NH:37][CH2:38][CH2:39][CH2:40][N:41]=1>C(Cl)Cl>[S:1]1[C:5]2[CH:6]=[CH:7][CH:8]=[CH:9][C:4]=2[N:3]=[C:2]1[NH:10][C@H:11]([C:28]([O:30][C:31]([CH3:32])([CH3:33])[CH3:34])=[O:29])[CH2:12][C:13]1[CH:14]=[CH:15][C:16]([O:19][CH2:20][CH2:21][CH2:22][C:23](=[O:25])[NH:35][C:36]2[NH:41][CH2:40][CH2:39][CH2:38][N:37]=2)=[CH:17][CH:18]=1

Participants

4

Reactant 2

HCID 32874121,4,5,6-Tetrahydropyrimidin-2-amineHCID 87970600HCID 87970600, compound

Product 1

HCID 86594977HCID 86594977, compoundYield 28.2%

Reagents, catalysts & solvents 1

HCID 6344DichloromethaneSolvent

Procedure

The ester 7-2 (80 mg) is mixed with 2-amino-1,4,5,6-tetrahydropyrimidine (40 mg) in 5 ml of CH2Cl2 and agitation is carried out at ambient temperature for 24 hours. After evaporating under reduced pressure, purifying the dry extract obtained by chromatography eluting with a CH2Cl2/MeOH mixture (100/0→90/10), 25 mg of the expected product 7-3 is obtained.

Workup

  1. customAfter evaporating under reduced pressure
  2. custompurifying the dry
  3. extractionextract
  4. customobtained by chromatography
  5. washeluting with a CH2Cl2/MeOH mixture (100/0→90/10)

Sources & evidence

ORD record
ord-b206308a8f1249c3b28f21c37874ed06
Source dataset
uspto-grants-2005_01
Patent number
US06838453B2

Reaction notes

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