HuagongsheHuagongshe Chemistry Print Report · For research reference only
1,4,5,6-Tetrahydropyrimidin-2-amine → HCID 86594977, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 1,4,5,6-Tetrahydropyrimidin-2-amine | HCID 3287412 | — |
| Reactant | HCID 87970600 | HCID 87970600 | — |
| Solvent | Dichloromethane | HCID 6344 | — |
| Product | HCID 86594977 | HCID 86594977 | 28.2% |
Reaction Steps
The ester 7-2 (80 mg) is mixed with 2-amino-1,4,5,6-tetrahydropyrimidine (40 mg) in 5 ml of CH2Cl2 and agitation is carried out at ambient temperature for 24 hours. After evaporating under reduced pressure, purifying the dry extract obtained by chromatography eluting with a CH2Cl2/MeOH mixture (100/0→90/10), 25 mg of the expected product 7-3 is obtained.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US06838453B2 |
| Source dataset | uspto-grants-2005_01 |
| ORD ID | ord-b206308a8f1249c3b28f21c37874ed06 |
| Source note | uspto-grants-2005_01 |