HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 1759712Generated: November 4, 2026
tert-Butyl (2S)-2-amino-3-(4-(3-ethoxycarbonylpropyloxy)phenyl)propionate → (1,1-dimethyl ethyl) N-(5-bromo-7-fluoro-2-benzoxazolyl)-O-(4-ethoxy-4-oxo-butyl)-L-tyrosinate
https://huagongshe.com/reaction/1759712
Participants
| Role | Name | HCID | Charge |
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| Reactant | tert-Butyl (2S)-2-amino-3-(4-(3-ethoxycarbonylpropyloxy)phenyl)propionate | HCID 15512208 | — |
| Reactant | 5-Bromo-7-fluoro-2-(methylthio)-benzoxazole | HCID 22599490 | — |
| Catalyst | Mercuric acetate | HCID 15337 | — |
| Product | (1,1-dimethyl ethyl) N-(5-bromo-7-fluoro-2-benzoxazolyl)-O-(4-ethoxy-4-oxo-butyl)-L-tyrosinate | HCID 69880648 | 40.5% |
Reaction Steps
The mixture constituted by aminoester 4-2 (865 mg; 2.46 mmoles), 5-bromo-7-fluoro-2-(methylthio)-benzoxazole (804 mg; 3.07 mmoles) and mercury diacetate (437 mg) is agitated for 3 hours, under nitrogen and at 100° C. After cooling down, the medium is chromatographed eluting with a CH2Cl2/ethyl acetate mixture 95/5, 564 mg of expected product is obtained, which is repurified by recrystallizing from isopropyl oxide. 528 mg of purified product is obtained.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
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| Patent number | US06838453B2 |
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| Source dataset | uspto-grants-2005_01 |
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| ORD ID | ord-57cb84ae0b3540efbaee501e8b58cb22 |
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| Source note | uspto-grants-2005_01 |
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