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HRID1759712

反应详情

EQUATION

反应方程式

HRID 1759712 的结构方程式

REACTANTS

反应物

2
结构：CCOC(=O)CCCOc1ccc(C[C@H](N)C(=O)OC(C)(C)C)cc1
HCID15512208

tert-Butyl (2S)-2-amino-3-(4-(3-ethoxycarbonylpropyloxy)phenyl)propionate

C19H29NO5

结构：CSc1nc2cc(Br)cc(F)c2o1
HCID22599490

未命名化合物

PRODUCTS

生成物

1
结构：CCOC(=O)CCCOc1ccc(C[C@H](Nc2nc3cc(Br)cc(F)c3o2)C(=O)OC(C)(C)C)cc1
HCID69880648

未命名化合物

收率 40.5%

AUXILIARIES

试剂、催化剂与溶剂

1
结构：CC(=O)[O-].CC(=O)[O-].[Hg+2]
催化剂HCID15337

Mercury(II) acetate

C4H6HgO4

CONDITIONS

反应条件

温度
100 °C

PROCEDURE

实验过程

The mixture constituted by aminoester 4-2 (865 mg; 2.46 mmoles), 5-bromo-7-fluoro-2-(methylthio)-benzoxazole (804 mg; 3.07 mmoles) and mercury diacetate (437 mg) is agitated for 3 hours, under nitrogen and at 100° C. After cooling down, the medium is chromatographed eluting with a CH2Cl2/ethyl acetate mixture 95/5, 564 mg of expected product is obtained, which is repurified by recrystallizing from isopropyl oxide. 528 mg of purified product is obtained.

WORKUP

后处理

  1. temperatureAfter cooling down
  2. customthe medium is chromatographed
  3. washeluting with a CH2Cl2/ethyl acetate mixture 95/5