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HRID1759716

反应详情

EQUATION

反应方程式

HRID 1759716 的结构方程式

REACTANTS

反应物

2
结构：COC(=O)CCc1ccc(C(=O)NC[C@H](N)C(=O)OC(C)(C)C)cc1
HCID15550489

未命名化合物

结构：CSc1nc2cc(Br)ccc2o1
HCID22495792

未命名化合物

PRODUCTS

生成物

1
结构：COC(=O)CCc1ccc(C(=O)NC[C@H](Nc2nc3cc(Br)ccc3o2)C(=O)OC(C)(C)C)cc1
HCID69733400

未命名化合物

收率 11.5%

AUXILIARIES

试剂、催化剂与溶剂

1
结构：CC(=O)[O][Hg][O]C(C)=O
催化剂HCID16683746

未命名化合物

CONDITIONS

反应条件

温度
75 °C

PROCEDURE

实验过程

A mixture constituted by 890 mg of 10-5, 620 mg of 5-bromo-2-methylthiobenzoxazole (prepared according to P1 but starting from 4-bromo-2-nitrophenol) and 350 mg of Hg(OAc)2 is heated for 2 hours at 75° C. then for 2 hours at 95° C. The cooled down medium is chromatographed eluting with a CH2Cl2/AcOEt mixture 82/18. 159 mg of expected product is obtained.

WORKUP

后处理

  1. temperatureThe cooled down medium
  2. customis chromatographed
  3. washeluting with a CH2Cl2/AcOEt mixture 82/18