HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 1759716Generated: October 26, 2026
(2S)-2-Amino-3-(4-(2-methoxycarbonyl-ethyl)-benzoylamino)-propionic acid tert-butyl ester → (1,1-dimethyl ethyl) N-(5-bromo-2-benzoxazolyl)-3-[[4-(3-methoxy-3-oxo-propyl)benzoyl]amino]-L-alaninate
https://huagongshe.com/reaction/1759716
Participants
| Role | Name | HCID | Charge |
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| Reactant | (2S)-2-Amino-3-(4-(2-methoxycarbonyl-ethyl)-benzoylamino)-propionic acid tert-butyl ester | HCID 15550489 | — |
| Reactant | 5-Bromo-2-(methylthio)benzo[d]oxazole | HCID 22495792 | — |
| Catalyst | Diacetyloxymercury | HCID 16683746 | — |
| Product | (1,1-dimethyl ethyl) N-(5-bromo-2-benzoxazolyl)-3-[[4-(3-methoxy-3-oxo-propyl)benzoyl]amino]-L-alaninate | HCID 69733400 | 11.5% |
Reaction Steps
A mixture constituted by 890 mg of 10-5, 620 mg of 5-bromo-2-methylthiobenzoxazole (prepared according to P1 but starting from 4-bromo-2-nitrophenol) and 350 mg of Hg(OAc)2 is heated for 2 hours at 75° C. then for 2 hours at 95° C. The cooled down medium is chromatographed eluting with a CH2Cl2/AcOEt mixture 82/18. 159 mg of expected product is obtained.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
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| Patent number | US06838453B2 |
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| Source dataset | uspto-grants-2005_01 |
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| ORD ID | ord-e67a84d2213346f387d660aea3079512 |
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| Source note | uspto-grants-2005_01 |
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