4-Fluorobenzaldehyde → 265113-47-1

HRID 1759792Notes

Reaction equation

HRID 1759792 reaction equation
[CH3:1][S:2]([C:5]1[CH:11]=[CH:10][C:8]([NH2:9])=[CH:7][CH:6]=1)(=[O:4])=[O:3].[F:12][C:13]1[CH:20]=[CH:19][C:16]([CH:17]=O)=[CH:15][CH:14]=1>C1(C)C=CC=CC=1>[F:12][C:13]1[CH:20]=[CH:19][C:16]([CH:17]=[N:9][C:8]2[CH:10]=[CH:11][C:5]([S:2]([CH3:1])(=[O:3])=[O:4])=[CH:6][CH:7]=2)=[CH:15][CH:14]=1

Participants

4

Reactant 2

HCID 680234-FluorobenzaldehydeHCID 796174-(Methylsulfonyl)aniline

Product 1

HCID 11097838265113-47-1

Reagents, catalysts & solvents 1

HCID 1140TolueneSolvent

Procedure

A mixture of 19.60 g (115 mmol) of 4-methylsulfonylaniline, 12.19 mL (115 mmol) of 4-fluorobenzaldehyde and 590 mL of toluene was refluxed in a Dean-Stark for 2 days. The solvent was removed and the crude product obtained was directly used in the next reaction.

Workup

  1. temperaturewas refluxed in a Dean-Stark for 2 days
  2. customThe solvent was removed

Sources & evidence

ORD record
ord-a20ef69699cf4e3296d198b4a78421e2
Source dataset
uspto-grants-2005_01
Patent number
US06838476B1

Reaction notes

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