Orotic Acid → Dicreatine orotate

HRID 1760058Notes

Reaction equation

HRID 1760058 reaction equation
O.[O:2]=[C:3]([CH2:5][N:6]([C:8](=[NH:10])[NH2:9])[CH3:7])[OH:4].[C:11]([OH:21])(=[O:20])[C:12]1[NH:19][C:17](=[O:18])[NH:16][C:14](=[O:15])[CH:13]=1>C(O)C>[C:11]([OH:21])(=[O:20])[C:12]1[NH:19][C:17](=[O:18])[NH:16][C:14](=[O:15])[CH:13]=1.[O:2]=[C:3]([CH2:5][N:6]([C:8](=[NH:9])[NH2:10])[CH3:7])[OH:4].[O:2]=[C:3]([CH2:5][N:6]([C:8](=[NH:9])[NH2:10])[CH3:7])[OH:4]

Participants

4

Reactant 2

HCID 967Orotic AcidHCID 80116Creatine Monohydrate

Product 1

HCID 131724698Dicreatine orotate

Reagents, catalysts & solvents 1

HCID 702EthanolSolvent

Procedure

Under room temperature 298 grams of creatine monohydrate is slowly added to 2.5 liters of ethanol under agitation and stirring for 30 minutes. Then 156 grams of orotic acid is slowly added to the mixture during continuous stirring for 4 hours under room temperature. Finally filtration is utilized to remove the solvent and clean the residue with ethanol. After drying 410 grams of Dicreatine orotate is obtained.

Workup

  1. stirringduring continuous stirring for 4 hours under room temperature
  2. filtrationFinally filtration
  3. customto remove the solvent
  4. dry with materialAfter drying 410 grams of Dicreatine orotate
  5. customis obtained

Sources & evidence

ORD record
ord-2117a84d62ec4ee484e6181dad9e3271
Source dataset
uspto-grants-2005_01
Patent number
US06838562B2

Reaction notes

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