Orotic Acid → Tricreatine orotate

HRID 1760059Notes

Reaction equation

HRID 1760059 reaction equation
O.[O:2]=[C:3]([CH2:5][N:6]([C:8](=[NH:10])[NH2:9])[CH3:7])[OH:4].[C:11]([OH:21])(=[O:20])[C:12]1[NH:19][C:17](=[O:18])[NH:16][C:14](=[O:15])[CH:13]=1>C(O)C>[C:11]([OH:21])(=[O:20])[C:12]1[NH:19][C:17](=[O:18])[NH:16][C:14](=[O:15])[CH:13]=1.[O:2]=[C:3]([CH2:5][N:6]([C:8](=[NH:9])[NH2:10])[CH3:7])[OH:4].[O:2]=[C:3]([CH2:5][N:6]([C:8](=[NH:9])[NH2:10])[CH3:7])[OH:4].[O:2]=[C:3]([CH2:5][N:6]([C:8](=[NH:9])[NH2:10])[CH3:7])[OH:4]

Participants

4

Reactant 2

HCID 967Orotic AcidHCID 80116Creatine Monohydrate

Product 1

HCID 11444210Tricreatine orotate

Reagents, catalysts & solvents 1

HCID 702EthanolSolvent

Procedure

Under room temperature 447 grams of creatine monohydrate is slowly added to 3.5 liters of ethanol under agitation and stirring for 30 minutes. Then 156 grams of orotic acid is slowly added to the mixture during continuous stirring for 4 hours under room temperature. Finally filtration is utilized to remove the solvent and clean the residue with alcohol. After drying 555 grams of Tricreatine orotate is obtained.

Workup

  1. stirringduring continuous stirring for 4 hours under room temperature
  2. filtrationFinally filtration
  3. customto remove the solvent
  4. dry with materialAfter drying 555 grams of Tricreatine orotate
  5. customis obtained

Sources & evidence

ORD record
ord-9ed86b6153574989bebfbce7cbe4d003
Source dataset
uspto-grants-2005_01
Patent number
US06838562B2

Reaction notes

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