Dichloromethane → N-[1-(4'-amino-4-biphenylyl)-2-(4-morpholinyl)ethyl]-2-(6,7-dichloro-3-oxo-2,3-dihydro-4H-1,4-benzoxazin-4-yl)-N-methylacetamide

HRID 176006Notes

Reaction equation

HRID 176006 reaction equation
[Cl:1][c:2]1[c:3]([Cl:46])[cH:4][c:5]2[c:6]([cH:45]1)[N:7]([CH2:12][C:13](=[O:14])[N:15]([CH:16]([CH2:17][N:18]1[CH2:19][CH2:20][O:21][CH2:22][CH2:23]1)[c:24]1[cH:25][cH:26][c:27](-[c:30]3[cH:31][cH:32][c:33]([NH:36][C:37](=[O:38])[O:39][C:40]([CH3:41])([CH3:42])[CH3:43])[cH:34][cH:35]3)[cH:28][cH:29]1)[CH3:44])[C:8](=[O:11])[CH2:9][O:10]2.[Cl:54][CH2:55][Cl:56].[OH:47][C:48]([C:49]([F:50])([F:51])[F:52])=[O:53]>>[Cl:1][c:2]1[c:3]([Cl:46])[cH:4][c:5]2[c:6]([cH:45]1)[N:7]([CH2:12][C:13](=[O:14])[N:15]([CH:16]([CH2:17][N:18]1[CH2:19][CH2:20][O:21][CH2:22][CH2:23]1)[c:24]1[cH:25][cH:26][c:27](-[c:30]3[cH:31][cH:32][c:33]([NH2:36])[cH:34][cH:35]3)[cH:28][cH:29]1)[CH3:44])[C:8](=[O:11])[CH2:9][O:10]2

Participants

4

Reactant 3

HCID 6344DichloromethaneHCID 6422Trifluoroacetic acidHCID 57488832HCID 57488832, compound

Product 1

HCID 46846402N-[1-(4'-amino-4-biphenylyl)-2-(4-morpholinyl)ethyl]-2-(6,7-dichloro-3-oxo-2,3-dihydro-4H-1,4-benzoxazin-4-yl)-N-methylacetamide

Sources & evidence

ORD record
ord-cacf2751fd8a46c1b766f5586972eca2
Source dataset
Training data from https://doi.org/10.1039/C8SC04228D (6/10)

Reaction notes

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