HCID 14697649, compound → HCID 86588935, compound

HRID 1760131Notes

Reaction equation

HRID 1760131 reaction equation
[CH3:1][CH:2]([CH3:21])[C@H:3]([O:12][CH2:13][O:14][CH2:15][CH2:16][Si:17]([CH3:20])([CH3:19])[CH3:18])[CH2:4][NH:5][C@H:6]([C:8]([O:10]C)=O)[CH3:7].[NH2:22][CH:23]1[C:29](=[O:30])[N:28]([CH3:31])[C:27]2[CH:32]=[CH:33][CH:34]=[CH:35][C:26]=2[N:25]([C:36]2[CH:41]=[CH:40][CH:39]=[CH:38][CH:37]=2)[C:24]1=[O:42]>>[CH3:21][CH:2]([CH3:1])[C@H:3]([O:12][CH2:13][O:14][CH2:15][CH2:16][Si:17]([CH3:20])([CH3:19])[CH3:18])[CH2:4][NH:5][C@H:6]([C:8]([C:23]1([NH2:22])[C:29](=[O:30])[N:28]([CH3:31])[C:27]2[CH:32]=[CH:33][CH:34]=[CH:35][C:26]=2[N:25]([C:36]2[CH:37]=[CH:38][CH:39]=[CH:40][CH:41]=2)[C:24]1=[O:42])=[O:10])[CH3:7]

Participants

3

Reactant 2

HCID 14697649HCID 14697649, compoundHCID 131723866HCID 131723866, compound2×

Product 1

HCID 86588935HCID 86588935, compound

Procedure

Following General Procedure II-A, Method B and using N-(3-methyl-2-(S)-(2-trimethylsilylethyloxy)methyloxybutyl)-L-alanine, methyl ester (Intermediate A, Step C; 1 eq), the free acid was prepared. The residue was used, following General Procedure D, and using 3-amino-2,4-dioxo-1-methyl-5-phenyl-2,3,4,5-tetrahydro-1H-1,5-benzodiazepine (CAS No. 131604-75-6) to prepare the title intermediate.

Workup

  1. customthe free acid was prepared

Sources & evidence

ORD record
ord-cc5b7ab9a342468a9967b250d3330b34
Source dataset
uspto-grants-2005_01
Patent number
US06838455B2

Reaction notes

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