Sodium Methoxide → HCID 12136955, compound

HRID 1760219Notes

Reaction equation

HRID 1760219 reaction equation
Cl[C:2]1[N:7]=[N:6][C:5]([N:8]2[C:16]([C:17]3[CH:22]=[CH:21][CH:20]=[C:19]([F:23])[CH:18]=3)=[N:15][C:14]3[C:9]2=[N:10][CH:11]=[N:12][C:13]=3[N:24]([CH3:26])[CH3:25])=[CH:4][CH:3]=1.[CH3:27][O-:28].[Na+]>CO>[F:23][C:19]1[CH:18]=[C:17]([C:16]2[N:8]([C:5]3[N:6]=[N:7][C:2]([O:28][CH3:27])=[CH:3][CH:4]=3)[C:9]3[C:14]([N:15]=2)=[C:13]([N:24]([CH3:26])[CH3:25])[N:12]=[CH:11][N:10]=3)[CH:22]=[CH:21][CH:20]=1

Participants

4

Reactant 2

HCID 10942334Sodium MethoxideHCID 12136954HCID 12136954, compound

Product 1

HCID 12136955HCID 12136955, compoundYield 53.2%

Reagents, catalysts & solvents 1

HCID 887MethanolSolvent

Procedure

N-[9-(6-Chloro-3-pyridazinyl)-8-(3-fluorophenyl)-9H-6-purinyl ]-N,N-dimethylamine (50 mg, 0.18 mmol) in Example 54 was dissolved in 5 ml anhydrous methanol, and sodium methoxide (15 mg, 0.28 mmol) was added thereto and heated under reflux for 2 hours. The reaction solution was cooled, evaporated and suspended in water, and the precipitated solid were separated by filtration, to give the title compound (35 mg, 52%) as a colorless solid.

Workup

  1. temperatureheated
  2. temperatureunder reflux for 2 hours
  3. temperatureThe reaction solution was cooled
  4. customevaporated
  5. customthe precipitated solid were separated by filtration

Sources & evidence

ORD record
ord-25d77f842c404ca3acae4f77d8753e13
Source dataset
uspto-grants-2005_01
Patent number
US06841549B1

Reaction notes

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