Sodium Methoxide → HCID 12136955, compound

Participants

Reaction Steps

N-[9-(6-Chloro-3-pyridazinyl)-8-(3-fluorophenyl)-9H-6-purinyl ]-N,N-dimethylamine (50 mg, 0.18 mmol) in Example 54 was dissolved in 5 ml anhydrous methanol, and sodium methoxide (15 mg, 0.28 mmol) was added thereto and heated under reflux for 2 hours. The reaction solution was cooled, evaporated and suspended in water, and the precipitated solid were separated by filtration, to give the title compound (35 mg, 52%) as a colorless solid.

Provenance & Evidence